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Related Concept Videos

Continuous Renal Replacement Therapy01:30

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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Related Experiment Video

Updated: Feb 15, 2026

Assessing the Coherence of Parents' Short Narratives Regarding their Child Using the Five-Minute Speech Sample Procedure
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Renal Replacement Therapy in the Critically Ill Child.

Claire A Westrope1, Sarah Fleming2, Melpo Kapetanstrataki2

  • 1Paediatric Intensive care Unit, University Hospitals Leicester NHS Trust, Leicester, United Kingdom.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|January 10, 2018
PubMed
Summary

This study analyzed renal replacement therapy (RRT) in UK pediatric intensive care units (PICUs). Overall survival was 73.8%, with factors like age and RRT type influencing outcomes.

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Area of Science:

  • Pediatric Critical Care Medicine
  • Nephrology
  • Epidemiology

Background:

  • Renal replacement therapy (RRT) is crucial for critically ill children.
  • Limited population-based data exists on RRT use and outcomes in pediatric intensive care units (PICUs).

Purpose of the Study:

  • To comprehensively describe RRT utilization and associated outcomes in critically ill children across the United Kingdom.
  • To identify factors influencing survival in this patient group.

Main Methods:

  • Retrospective observational study using prospectively collected data from the Pediatric Intensive Care Audit Network (PICANet) database.
  • Inclusion of children (<16 years) admitted to UK PICUs between 2005 and 2012 who received RRT.
  • Extraction of individual-level data on demographics, diagnosis, RRT modality, duration, PICU stay, and survival.

Main Results:

  • 2.9% (3,825/129,809) of PICU admissions received RRT across 30 centers.
  • Overall survival to PICU discharge was 73.8%, higher than previous reports.
  • Mortality risk was associated with younger age (neonates), peritoneal dialysis use, longer RRT duration, and primary diagnosis (lowest survival in liver disease).

Conclusions:

  • This study provides a large UK-based cohort analysis of pediatric RRT use and outcomes.
  • Key factors influencing survival include age, RRT modality, duration, and underlying diagnosis.
  • Findings will inform future clinical trial design for critically ill children requiring RRT.