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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Autoimmunity and autoimmune co-morbidities in psoriasis.

Kazuhisa Furue1, Takamichi Ito1, Gaku Tsuji1

  • 1Department of Dermatology, Kyushu University, Fukuoka, Japan.

Immunology
|January 10, 2018
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Summary

Psoriasis involves scaly plaques and inflammation driven by the tumor necrosis factor-α/interleukin-23/interleukin-17 pathway. This review covers psoriasis autoimmunity and its links to other autoimmune conditions.

Keywords:
alopeciaautoimmunitybullous pemphigoidpsoriasisthyroiditisvitiligo

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Area of Science:

  • Dermatology
  • Immunology
  • Autoimmunity

Background:

  • Psoriasis presents as scaly, erythematous plaques, causing significant physical and psychological distress.
  • The tumor necrosis factor-alpha/interleukin-23/interleukin-17 inflammatory axis is a key mechanism in psoriasis development.
  • Psoriasis exhibits autoimmune characteristics, including autoreactive T cells and frequent comorbidities with other autoimmune diseases.

Purpose of the Study:

  • To review recent advancements in understanding psoriasis autoimmunity.
  • To explore the spectrum of autoimmune comorbidities associated with psoriasis.

Main Methods:

  • Literature review of recent research on psoriasis, autoimmunity, and comorbidities.
  • Synthesis of current knowledge on the immunological mechanisms underlying psoriasis.
  • Analysis of epidemiological and clinical data on psoriasis comorbidities.

Main Results:

  • The tumor necrosis factor-alpha/interleukin-23/interleukin-17 axis plays a central role in psoriasis pathogenesis.
  • Psoriasis is frequently comorbid with autoimmune bullous diseases, vitiligo, alopecia, and thyroiditis.
  • Autoreactive T cells are a hallmark of psoriasis, underscoring its autoimmune nature.

Conclusions:

  • Understanding the autoimmune basis of psoriasis is crucial for developing targeted therapies.
  • Recognizing and managing autoimmune comorbidities can improve patient outcomes in psoriasis.
  • Further research into the shared immunological pathways in psoriasis and its comorbidities is warranted.