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Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine
Daniel A Foyt1, Michael D A Norman1, Tracy T L Yu1
1Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK.
Advanced Healthcare Materials
|January 10, 2018
Summary
Hydrogels are advanced materials used in regenerative medicine to repair tissues and create 3D models. Controlled hydrogel properties enable precise tissue engineering for future clinical applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Hydrogels, water-swollen polymer networks, are crucial in regenerative medicine for tissue repair and disease modeling.
- Advances in hydrogel chemistry enable the creation of biomimetic 3D ex vivo tissue models with dynamic physical properties.
Purpose of the Study:
- To review recent advances in hydrogel design and fabrication for regenerative medicine.
- To explore how controlled hydrogel chemistries facilitate precise engineering of spatiotemporal properties.
- To discuss the translation of advanced hydrogels to clinical applications.
Main Methods:
- Utilizing advanced hydrogel chemistries to create biomimetic 3D tissue models.
- Employing techniques like 3D bioprinting for cell-laden hydrogels with controlled architectures.
- Developing in situ forming and acellular hydrogels as delivery vehicles and for modulating host responses.
Main Results:
- Engineered hydrogels serve as sophisticated 3D ex vivo models for cell biology research.
- Cell-laden hydrogels with tailored architectures and functions promote tissue repair.
- In situ forming and acellular hydrogels show promise as delivery systems and in host response modulation.
Conclusions:
- Controlled hydrogel chemistry allows precise engineering of material properties for regenerative medicine.
- Advanced hydrogels are pivotal for developing functional tissue models and therapeutic strategies.
- Future clinical applications of engineered hydrogels are anticipated with continued material development.
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