Related Experiment Video
Updated: Feb 15, 2026
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
14.8K
Targeting FLT3 Mutations in Acute Myeloid Leukemia
Riad El Fakih1, Walid Rasheed2, Yousef Hawsawi3
1King Faisal Specialist Hospital and Research Center Riyadh, Riyadh 11211, Saudi Arabia. relfakih1@kfshrc.edu.sa.
Cells
|January 11, 2018
Summary
FLT3 inhibitors are crucial for treating acute myeloid leukemia (AML) with FLT3 mutations. Second-generation inhibitors offer improved specificity and potency across all AML treatment phases.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- The FMS-like tyrosine kinase 3 (FLT3) pathway regulates critical cell functions.
- Mutated FLT3 in acute myeloid leukemia (AML) correlates with high disease burden and poor prognosis.
Purpose of the Study:
- To review the clinical application of FLT3 inhibitors in AML treatment.
Main Methods:
- Review of existing literature on FLT3 inhibitors and their use in AML.
- Comparison of first-generation (non-specific) and second-generation (specific, potent) FLT3 inhibitors.
Main Results:
- FLT3 inhibitors are utilized across all stages of AML, including induction, consolidation, maintenance, relapse, and post-hematopoietic cell transplantation (HCT).
- Second-generation inhibitors demonstrate enhanced specificity and potency.
Conclusions:
- FLT3 inhibitors represent a vital therapeutic strategy for FLT3-mutated AML.
- The evolving landscape of FLT3 inhibitors offers improved treatment options for AML patients.
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