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Related Experiment Video

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A Fabrication Method for Highly Stretchable Conductors with Silver Nanowires
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Highly stretchable HA/SA hydrogels for tissue engineering.

Chengcheng Zhu1, Rui Yang1, Xiaobin Hua1

  • 1a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, Department of Product Engineering, School of Chemical Engineering , East China University of Science and Technology , Shanghai , China.

Journal of Biomaterials Science. Polymer Edition
|January 11, 2018
PubMed
Summary
This summary is machine-generated.

This study developed a highly stretchable hyaluronic acid (HA) and sodium alginate (SA) hydrogel using interpenetrating polymer networks. The optimized HA/SA hydrogel demonstrated excellent protein retention and supported cell growth, showing promise for tissue regeneration applications.

Keywords:
Hydrogeldrug releasehyaluronic acidregenerationstretch

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Developing advanced hydrogels is crucial for tissue regeneration.
  • Hyaluronic acid (HA) and sodium alginate (SA) are biocompatible polysaccharides with potential for hydrogel formation.
  • Interpenetrating polymer networks (IPNs) offer enhanced mechanical properties and tunable characteristics.

Purpose of the Study:

  • To develop a highly stretchable HA/SA hydrogel using sequential covalent and ionic crosslinking.
  • To investigate the impact of HA/SA ratios on hydrogel properties, including mechanical strength, swelling, and protein release.
  • To evaluate the potential of surface-modified HA/SA hydrogels for cell adhesion and tissue engineering applications.

Main Methods:

  • Preparation of HA/SA hydrogels via sequential covalent and ionic crosslinking.
  • Characterization of hydrogel properties: pore size, swelling ratio, rheology, and elongation at break.
  • Assessment of protein loading and in vitro release kinetics.
  • Surface modification using layer-by-layer (LBL) assembly.
  • Evaluation of cell (fibroblast and keratinocyte) adhesion and growth on hydrogel surfaces.

Main Results:

  • The developed HA/SA hydrogels exhibited tunable pore sizes (50-100 μm) and swelling ratios.
  • Increased SA content led to decreased pore size, swelling, and rheological moduli, but accelerated weight loss.
  • The HA8/SA1 hydrogel achieved a maximum elongation at break of 417% and retained 33.2% protein after 72 hours.
  • LBL modification enhanced protein retention and promoted keratinocyte adhesion on the HA8/SA1 hydrogel.

Conclusions:

  • A highly stretchable and robust HA/SA IPN hydrogel was successfully fabricated.
  • The HA/SA ratio significantly influences hydrogel physicochemical and mechanical properties.
  • The modified HA/SA hydrogel demonstrates excellent protein retention and biocompatibility, making it a promising scaffold for skin tissue engineering.