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Updated: Feb 15, 2026

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Ileal mucosal response to the same probiotic Lactobacillus strains is markedly different between suckling and adult
Ryo Inoue1, Shigeru Fujiwara2, Takamitsu Tsukahara3
1a Laboratory of Animal Science , Kyoto Prefectural University , Kyoto , Japan.
Abstract:
While evidence shows that probiotic supplementation exerts beneficial effects on developing children and animals, it is unclear whether it would exert equal or similar effects on adult human and animals. In this study, response to probiotic lactobacilli in ileal mucosa of suckling and adult mice was compared by evaluating gene expression profiles using DNA microarray. Two probiotic strains, Lactobacillus gasseri CP2305s and Lactobacillus plantarum CPA305C were used. Supplementation of probiotics for 7 days affected completely different genes in suckling and adult mice, regardless of the probiotic strain. The results suggested that ileal mucosal responses to probiotics are age stage specific.
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