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Updated: Feb 15, 2026
05:39
Murine Model of Wound Healing
Published on: May 28, 2013
67.6K
Microvesicles: Intercellular messengers in cutaneous wound healing.
Alexandra Laberge1, Syrine Arif1, Véronique J Moulin1,2
1Centre de recherche en organogenese experimentale de l'Université Laval/LOEX, Centre de recherche du CHU de Quebec, Quebec, Canada.
Journal of Cellular Physiology
|January 11, 2018
Summary
Microvesicles (MVs), once thought inert, are key players in cell communication and wound healing. This review explores their biogenesis, actions, and roles in the skin
Area of Science:
- Cell Biology
- Dermatology
- Regenerative Medicine
Background:
- Microvesicles (MVs) were historically dismissed as cellular debris.
- Recent research highlights MVs as crucial mediators of intercellular communication.
- Their involvement spans various physiological and pathological processes.
Purpose of the Study:
- To review the significant role of microvesicles in wound healing.
- To elucidate the biogenesis and mechanisms of action of MVs.
- To explore the functions of MVs in distinct phases of skin repair.
Main Methods:
- Literature review of current research on microvesicles and wound healing.
- Synthesis of existing knowledge on MV biogenesis and intercellular signaling.
- Analysis of MV contributions to hemostatic, inflammatory, proliferative, and remodeling stages.
Main Results:
- Microvesicles are actively released from cells via plasma membrane budding and fission.
- MVs play dynamic roles throughout the wound healing cascade.
- They are integral to intercellular communication during skin homeostasis and repair.
Conclusions:
- Microvesicles are essential regulators of cell-to-cell interactions in wound healing.
- Understanding MV dynamics offers new insights into skin repair mechanisms.
- MVs represent a promising area for therapeutic interventions in regenerative medicine.
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