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Updated: Feb 15, 2026

P50 Sensory Gating in Infants
Published on: December 26, 2013
COMT Genotype and Sensory and Sensorimotor Gating in High and Low Hypnotizable Subjects
Zinaida I Storozheva1, Anna V Kirenskaya1, Mikhail N Gordeev2
1a V. Serbsky Federal Medical Research Centre for Psychiatry and Narcology , Moscow , Russia.
Abstract:
We investigated the association between hypnotizability, COMT polymorphism, P50 suppression ratio, and prepulse inhibition of acoustic startle response (ASR) in 21 high (HH) and 19 low (LH) hypnotizable subjects. The frequency of Met/Met carriers of COMT polymorphysm was higher in HH than in LH group (33.3% versus 10.6%, p = .049). Increased ASR amplitude and latency and decreased prepulse inhibition at 120 ms lead interval were found in the HH compared to the LH group. The effect of COMT genotype on prepulse inhibition was observed in LH group only. No between-group differences in P50 measures were found. The obtained results suppose the participation of dopamine system in mechanisms of hypnotizability and different allocation of attentional resources in HH and LH subjects.
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