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Cardiometabolic effects of psychotropic medications

Oluchi Abosi1, Sneha Lopes1, Samantha Schmitz1,2

  • 1Department of Psychiatry, The University of Iowa, Iowa City, IA, USA.

Hormone Molecular Biology and Clinical Investigation
|January 11, 2018
PubMed

Insights

Psychiatric medications can increase cardiovascular risks like obesity and high blood pressure. Understanding and managing these cardiometabolic side effects is crucial for patient health.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Cardiology

Background:

  • Psychiatric disorders are linked to higher cardiovascular disease (CVD) rates.
  • Psychotropic medications may worsen cardiovascular risk, especially in vulnerable groups.
  • A need exists to understand the cardiometabolic effects of these drugs.

Purpose of the Study:

  • To review the cardiometabolic adverse effects of psychotropic medications.
  • To detail the molecular and physiological mechanisms behind these effects.
  • To organize findings around metabolic syndrome components.

Main Methods:

  • Literature review of relevant studies.
  • Focus on commonly prescribed psychotropic medications.
  • Analysis of associations with metabolic syndrome components.

Main Results:

  • Antipsychotics, mood stabilizers, and some antidepressants are linked to insulin resistance, obesity, and dyslipidemia.
  • Stimulants, certain antidepressants, and valproic acid derivatives can elevate blood pressure.
  • Significant variability in risk exists between different medications and individuals.

Conclusions:

  • Managing psychotropic-induced cardiometabolic effects is vital to reduce CVD morbidity and mortality.
  • Assessing and monitoring these side effects is critical for at-risk patients.
  • Individualized management strategies are necessary due to variable risks.

Keywords:
adverse effectsanticonvulsantsantidepressive agentsantipsychoticsdiabetes mellitusdyslipidemiaslithiummetabolic syndromepsychotropic drugsweight gain

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