Eruptive Sebaceous Hyperplasia: A Rare Consequence of Systemic Corticosteroids

Area of Science:

• Dermatology
• Immunosuppression
• Gastroenterology

Background:

• Eruptive sebaceous hyperplasia is a rare condition linked to immunosuppression, typically cyclosporine after organ transplantation.
• No prior cases linked this condition to immunosuppression outside of organ transplant recipients.

Observation:

• A 43-year-old male with Crohn's disease developed multiple asymptomatic papules on his face.
• These lesions appeared weeks after initiating a prednisone taper for a Crohn's exacerbation.
• Clinical and histological examination confirmed sebaceous hyperplasia.

Findings:

• This is the first reported instance of eruptive sebaceous hyperplasia associated with prednisone use in a Crohn's disease patient.
• The condition manifested as multiple small, dome-shaped, umbilicated papules on the face.

Implications:

• This case highlights prednisone-induced sebaceous hyperplasia as a potential side effect.
• Educating Crohn's disease patients about this possible adverse reaction to prednisone is crucial.