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Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
Published on: January 6, 2023
SERCA2b Cycles Its Way to UCP1-Independent Thermogenesis in Beige Fat
Emilio P Mottillo1, Vanesa D Ramseyer1, James G Granneman1
1Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, MI 48202, USA.
Abstract:
A new study in Nature Medicine, by Ikeda et al. (2017), reports that calcium cycling in beige adipocytes elevates energy expenditure and glucose oxidation in the absence of uncoupling protein 1. Thermogenic calcium cycling in beige fat is mediated by SERCA2b and improves cold tolerance and metabolic status.
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