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Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
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A glucose-responsive insulin therapy protects animals against hypoglycemia

Ruojing Yang, Margaret Wu, Songnian Lin

    JCI Insight
    |January 12, 2018
    PubMed
    Summary

    Mannosylated insulin analogs offer glucose-responsive release, enhancing insulin therapy safety and efficacy. These analogs interact with mannose receptors (MR) and insulin receptors (IR) in a glucose-dependent manner for improved glycemic control.

    Keywords:
    DiabetesEndocrinologyGlucose metabolismInsulinMetabolism

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