Related Experiment Video
Updated: Feb 15, 2026

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
Construction and Use of Staphylococcus aureus Strains to Study Within-Host Infection Dynamics
Gareth McVicker1,2,3, Tomasz K Prajsnar1,2,3, Simon J Foster4,5,6
1Krebs Institute, University of Sheffield, Sheffield, UK.
Abstract:
The study of the dynamics that occur during the course of a bacterial infection has been attempted using several methods. Here we discuss the construction of a set of antibiotic-resistant, otherwise-isogenic Staphylococcus aureus strains that can be used to observe the progress of systemic disease in a mouse model at various time-points postinfection. The strains can likewise be used to study the progression of infection in other animal infection models, such as the zebrafish embryo. Furthermore, the use of antibiotic resistance tags provides a convenient system with which to investigate the effect of antimicrobial chemotherapy during disease.
Related Concept Videos
Thermal Strain
Shearing Strain
Measurements of Strain
Dynamic Equilibrium
Strain Energy
Consider a rod that is fixed at one end and subjected to an axial force at the free end. This axial force induces stress within the rod, leading to its elongation. As the axial force increases, so does the elongation of the rod, illustrating a direct relationship between the force applied and the resulting...
Problem Solving on Stress and Strain

