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The multifaceted link between inflammation and human diseases.

Peramaiyan Rajendran1, Ya-Fang Chen2,3, Yu-Feng Chen4

  • 1Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

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|January 12, 2018
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Summary
This summary is machine-generated.

Chronic inflammation, marked by mononuclear cell infiltration and tissue damage, is linked to numerous diseases like cancer and arthritis. Understanding inflammatory agents is key to addressing these chronic conditions.

Keywords:
arthritisatherosclerosiscancerinflammationneurological disorders

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Area of Science:

  • Immunology and Pathology

Background:

  • Dysfunction of the inflammatory reaction is increasingly associated with chronic illnesses including cancer, arthritis, arteriosclerosis, neurological, liver, and renal disorders.
  • Chronic inflammation is characterized by mononuclear cell infiltration, tissue destruction, and repair attempts, differing from acute inflammation.
  • Phagocytes play a central role, but their pathological activation due to persistent tissue damage can lead to detrimental diseases.

Purpose of the Study:

  • To review advances in understanding chronic inflammation.
  • To summarize the impact and involvement of inflammatory agents in specific human diseases.

Main Methods:

  • Literature review focusing on epidemiological, diagnostic, and clinical studies.
  • Analysis of the role of inflammatory processes and agents in chronic disease pathogenesis.

Main Results:

  • Chronic inflammation is a significant factor in the development and progression of various severe human diseases.
  • Persistent inflammation, particularly pathological phagocyte activation, exacerbates tissue damage and disease establishment.
  • Understanding specific inflammatory agents is crucial for comprehending their involvement in diseases like cancer and arthritis.

Conclusions:

  • Chronic inflammation is a critical pathway implicated in a wide spectrum of human pathologies.
  • Further research into inflammatory agents and mechanisms is essential for developing therapeutic strategies against chronic diseases.