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Brain Functional Changes before, during, and after Clinical Pain.

X Hu1,2, A J Racek1, E Bellile1,3

  • 11 Headache & Orofacial Pain Effort, Biologic & Materials Sciences Department, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

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|January 12, 2018
PubMed
Summary
This summary is machine-generated.

Functional near-infrared spectroscopy (fNIRS) reveals brain activity patterns predicting dental pain. Baseline connectivity and hemodynamic responses in S1 and PFC influence pain perception and alter brain connectivity post-pain.

Keywords:
clinical settingdental painfunctional near-infrared spectroscopyprefrontal cortexresting-state functional connectivitysomatosensory cortex

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Pain Research

Background:

  • Dental hypersensitivity involves complex pain experiences.
  • Understanding brain mechanisms during clinical pain is crucial.
  • Functional near-infrared spectroscopy (fNIRS) is an emerging tool for brain imaging.

Purpose of the Study:

  • To investigate functional brain activation and connectivity modulating pain in a clinical dental setting.
  • To link hemodynamic responses and functional connectivity with clinical pain experience.
  • To explore brain changes before, during, and after pain induction.

Main Methods:

  • Used fNIRS to record hemodynamic responses at somatosensory cortices (S1) and prefrontal cortices (PFCs).
  • Recruited 12 patients with dentin hypersensitivity undergoing cold stimulation.
  • Applied partial least squares path modeling to analyze pain experience, hemodynamic responses, and resting-state functional connectivity (RSFC).

Main Results:

  • Hemodynamic responses in PFC/S1 were sequentially linked to expectation, cold detection, and pain perception.
  • Pain ratings were moderately associated with functional activation sequences and baseline PFC-S1 RSFC.
  • Post-pain, PFC connectivity increased with contralateral S1 and decreased with ipsilateral S1 regions.

Conclusions:

  • Clinical dental pain experience can be predicted by baseline S1-PFC functional connectivity and ongoing hemodynamic responses.
  • Brain connectivity shows immediate after-effects post-pain, even after pain cessation.
  • Findings enhance understanding of affective and sensory experience impacts on the brain during and after clinical pain.