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Peripheral serotonin2 receptor blockade does not inhibit 5-hydroxytryptophan-induced aldosterone stimulation
The Journal of Clinical Endocrinology and Metabolism
|December 1, 1985
Summary
Serotonin (5-hydroxytryptophan) increases aldosterone secretion, even when serotonin2 receptors are blocked. This suggests central pathways, not peripheral ones, mediate this effect in normal men.
Area of Science:
- Endocrinology
- Neuropharmacology
- Physiology
Background:
- Serotonin plays a role in regulating various physiological processes, including hormone secretion.
- The specific pathways mediating 5-hydroxytryptophan (5HTP)-induced aldosterone secretion are not fully understood.
Purpose of the Study:
- To investigate the role of serotonin receptor blockade in 5-hydroxytryptophan (5HTP)-induced aldosterone secretion.
- To determine if peripheral serotonin2 receptors mediate the aldosterone response to 5HTP.
Main Methods:
- Six healthy men participated in a study involving three separate occasions.
- Subjects received dexamethasone pretreatment, with two occasions including serotonin antagonists ketanserin or methysergide.
- A single oral dose of 5HTP (200 mg) was administered on the day of study.
Main Results:
- Plasma aldosterone levels significantly increased after 5HTP administration compared to basal levels.
- No significant difference in aldosterone response was observed across the three study conditions.
- Peripheral blockade of serotonin2 receptors did not abolish 5HTP-induced aldosterone stimulation.
Conclusions:
- Peripheral serotonin2 receptor blockade does not inhibit 5-hydroxytryptophan (5HTP)-induced aldosterone secretion.
- The aldosterone stimulation by 5HTP is likely mediated by central nervous system pathways.