Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
What is a Nervous System?01:25

What is a Nervous System?

105.4K
Overview
105.4K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

116.0K
Overview
116.0K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

104.1K
Overview
104.1K
Nervous System01:21

Nervous System

3.6K
The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aberrant medial ganglionic eminence (MGE) GABAergic neurogenesis contributes to Huntington's disease pathogenesis.

Neurobiology of disease·2026
Same author

Mouse models to interrogate the developmental pathogenesis of Huntington's disease.

Journal of Huntington's disease·2026
Same author

Prognostic value of plasma biomarkers for informing clinical trial design in mild-to-moderate Alzheimer's disease.

Alzheimer's research & therapy·2025
Same author

Verdiperstat in Amyotrophic Lateral Sclerosis: Results From the Randomized HEALEY ALS Platform Trial.

JAMA neurology·2025
Same author

Targeting Myeloperoxidase to Reduce Neuroinflammation in X-Linked Dystonia Parkinsonism.

CNS neuroscience & therapeutics·2024
Same author

Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice.

Journal of neurochemistry·2024

Related Experiment Video

Updated: Feb 15, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
05:10

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

6.5K

Epigenetic mechanisms underlying nervous system diseases.

Irfan A Qureshi1, Mark F Mehler2

  • 1Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine; Institute for Brain Disorders and Neural Regeneration; Departments of Neurology, Neuroscience, Psychiatry and Behavioral Sciences and Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY, United States.

Handbook of Clinical Neurology
|January 13, 2018
PubMed
Summary

Epigenetic mechanisms control gene activity by modifying DNA and proteins, influencing cell function and development. These processes are crucial for nervous system function, aging, and disease.

Keywords:
DNA methylationRNA editingchromatinepigenetichistone modificationnoncoding RNAtransgenerational inheritance

More Related Videos

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

10.1K
Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
07:00

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

Published on: February 26, 2019

10.1K

Related Experiment Videos

Last Updated: Feb 15, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
05:10

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

6.5K
ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

10.1K
Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
07:00

Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

Published on: February 26, 2019

10.1K

Area of Science:

  • Molecular Biology
  • Genetics
  • Neuroscience

Background:

  • Epigenetic mechanisms regulate genomic structure and activity in response to various signals.
  • These processes mediate cell- and tissue-specific gene expression, function, and interactions.
  • Major mechanisms include DNA methylation, histone modifications, and noncoding RNA regulation.

Purpose of the Study:

  • To explore the role of epigenetic mechanisms in fundamental genomic programs.
  • To understand how epigenetics influences nervous system development, aging, and function.
  • To investigate the involvement of epigenetics in nervous system disease pathophysiology.

Main Methods:

  • Review of major epigenetic mechanisms (DNA methylation, histone modifications, noncoding RNA).
  • Analysis of epigenetic involvement in gene transcription, RNA processing, translation, and DNA repair.
  • Examination of epigenetic roles in neural development, plasticity, and transgenerational inheritance.
  • Investigation of epigenetic factors in nervous system disease.

Main Results:

  • Epigenetic mechanisms are integral to gene expression, DNA repair, and genomic stability.
  • Epigenetics provides a framework for understanding brain development, aging, and neural diversity.
  • Epigenetic dysregulation is implicated in nervous system diseases through various mechanisms.

Conclusions:

  • Epigenetic mechanisms are fundamental regulators of cellular processes and genomic stability.
  • Epigenetics offers critical insights into nervous system function, development, and disease.
  • Further research into epigenetic factors is vital for understanding and treating neurological disorders.