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Related Concept Videos

Murine Nasal Lavage Fluid Collection without Blood Contamination05:12

Murine Nasal Lavage Fluid Collection without Blood Contamination

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The present protocol describes a novel method for avoiding blood contamination in murine nasal lavage fluid (NLF). Since this method ensures the NLF collection without blood contamination, it allows for more accurate detections of immunological components and various respiratory...
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OSTSS leads to pooled inflammatory mediators in the tear film, causing symptoms like epiphora and discomfort. Here, we present a case where therapeutic nasolacrimal lavage every 2 months resolved epiphora and itchiness, suggesting its efficacy as a therapeutic intervention for OSTSS. Additionally, we report subjective improvements in symptoms in 3 additional...
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Saline nasal lavage can be used to sample the canine nasal immune microenvironment. Because the approach is relatively non-invasive and does not disrupt the nasal tissues, it can be performed serially. Cells and proteins collected from the nasal lavage technique can be processed for various laboratory analyses.
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A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental...
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Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians06:49

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Batrachochytrium dendrobatidis infection in amphibians can be eliminated using a reduced concentration (0.0025%) and shorter duration (five minute baths for six days) of itraconazole than is generally used. Less mortality and fewer negative side effects were observed using this modified treatment...
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A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic...
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Related Experiment Video

Updated: Jan 7, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
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EMT in cancer.

Thomas Brabletz1, Raghu Kalluri2, M Angela Nieto3

  • 1Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, FAU University Erlangen-Nürnberg, Glückstr. 6, 91054 Erlangen, Germany.

Nature Reviews. Cancer
|January 13, 2018
PubMed
Summary

Epithelial to mesenchymal transition (EMT) is crucial in cancer development and progression. This study explores expert opinions on EMT

Area of Science:

  • Oncology
  • Cell Biology
  • Developmental Biology

Background:

  • Epithelial to mesenchymal transition (EMT) is a process observed in embryonic development and cancer.

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  • While initially studied in cell cultures, EMT's role in vivo in cancer is increasingly reported but remains debated.
  • The complexity of EMT in cancer presents numerous open research questions.