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The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model

Burak Turgut1, İrfan Ergen2, Nevin İlhan3

  • 1Yüksek İhtisas University Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

Turkish Journal of Ophthalmology
|January 13, 2018
PubMed

Insights

Sesamol demonstrated protective effects against experimental cataracts in rats. This antioxidant compound significantly reduced cataract formation by improving lens health and reducing oxidative stress.

Area of Science:

  • Biochemistry
  • Ophthalmology
  • Pharmacology

Background:

  • Cataract is a leading cause of vision impairment globally.
  • Oxidative stress plays a crucial role in cataractogenesis.
  • Sesamol, a natural compound, possesses antioxidant properties.

Purpose of the Study:

  • To evaluate the potential of sesamol in preventing sodium selenite-induced experimental cataracts.
  • To investigate the impact of sesamol on oxidative stress markers in the lens.

Main Methods:

  • An experimental cataract model was established in Sprague Dawley rat pups using sodium selenite.
  • Rats were treated with either saline (sham group) or sesamol.
  • Lens biochemical analysis included reduced glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS), and total oxidant status (TOS).

Main Results:

  • Sesamol treatment significantly reduced the mean cataract grade compared to the sham group.
  • Sesamol administration led to significantly higher GSH and TAS levels in the lens.
  • Sesamol treatment resulted in significantly lower MDA and TOS levels in the lens.

Conclusions:

  • Sesamol exhibits significant protective effects against experimental cataracts.
  • Sesamol ameliorates oxidative stress in the lens by modulating GSH, TAS, TOS, and MDA levels.
  • Sesamol holds potential as a therapeutic agent for cataract prevention.
Abstract

Keywords:
Sodium seleniteexperimental cataractsesamol

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