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High nuclear MSK1 is associated with longer survival in breast cancer patients

Xuan Pu1, Sarah J Storr1, Narmeen S Ahmad1

  • 1University of Nottingham, Division of Cancer and Stem Cells, Department of Clinical Oncology, School of Medicine, Nottingham University Hospitals NHS Trust, City Hospital Campus, Nottingham, UK.

Journal of Cancer Research and Clinical Oncology
|January 13, 2018
PubMed
Abstract

Insights

High MSK1 protein expression is linked to better survival in early breast cancer patients. While not an independent marker, its association with known negative prognostic factors warrants further study.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Mitogen- and stress-activated kinases (MSKs), including MSK1 and MSK2, are nuclear serine/threonine protein kinases.
  • MSK1 has been implicated in breast cancer cell proliferation, cell cycle progression, migration, invasion, and tumor growth.

Purpose of the Study:

  • To assess MSK1 protein expression in breast cancer tumor specimens.
  • To evaluate the prognostic significance of MSK1 expression in early-stage invasive breast cancer.

Main Methods:

  • Utilized a cohort of 1902 early-stage invasive breast cancer patients.
  • Examined MSK1 protein expression using standard immunohistochemistry on tissue microarrays.

Main Results:

  • Low MSK1 expression correlated with younger age, higher tumor grade, higher Nottingham Prognostic Index, negative ER/PR status, and triple-negative/basal-like phenotypes.
  • Low MSK1 expression was significantly associated with shorter time to distant metastasis, recurrence, and early death.
  • High MSK1 expression was linked to improved breast cancer-specific survival, particularly in HER2-negative and non-basal like tumors.

Conclusions:

  • High MSK1 expression is associated with improved breast cancer-specific survival in early-stage invasive breast cancer.
  • MSK1 has additional prognostic value in HER2-negative and non-basal like disease.
  • Despite not being an independent marker, MSK1's associations with established negative prognostic factors suggest further investigation and validation in independent cohorts are warranted.
Keywords:
BiomarkerBreast cancerBreast cancer-specific survivalMSK

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