Related Experiment Video
Updated: Feb 15, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract
Claudia Dalke1, Frauke Neff2,3, Savneet Kaur Bains4,5
1Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, 85764, Neuherberg, Germany.
Abstract:
Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.
More Related Videos
06:21Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
Published on: May 27, 2016
06:20Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Related Concept Videos
Biological Effects of Radiation
Bioavailability Study Design: Single Versus Multiple Dose Studies
Acute Pyelonephritis II: Diagnostic Studies and Management
Ionization Energy
Acute Coronary Syndrome III: Diagnostic Studies
Case Studies