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Updated: Feb 15, 2026
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E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
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Gastroenterology today: between certainties and news
Rinaldo Pellicano1, Davide G Ribaldone2,3, Marco Astegiano1
1Unit of Gastroenterology, Molinette Hospital, Turin, Italy.
Minerva Gastroenterologica E Dietologica
|January 13, 2018
Summary
Updated Helicobacter pylori (H. pylori) management favors bismuth quadruple therapy due to rising antibiotic resistance. Dysbiosis research is crucial for treating conditions like irritable bowel syndrome (IBS-C).
Area of Science:
- Gastroenterology
- Microbiology
- Internal Medicine
Background:
- Emerging antibiotic resistance in Helicobacter pylori (H. pylori) necessitates updated treatment guidelines.
- Intestinal microbiota dysbiosis is increasingly linked to gastrointestinal disorders, including constipation-predominant irritable bowel syndrome (IBS-C) and microscopic colitis.
Purpose of the Study:
- To present updated management strategies for H. pylori infection, focusing on novel treatments.
- To discuss recent advancements in understanding intestinal microbiota dysbiosis and its clinical implications, particularly for IBS-C and microscopic colitis.
Main Methods:
- Review of recent European Guidelines for H. pylori management.
- Discussion of novel therapeutic approaches for H. pylori infection, including bismuth-containing quadruple therapies and levofloxacin/rifabutin-based regimens.
- Exploration of the role of dysbiosis in IBS-C and microscopic colitis, highlighting the need for further research.
Main Results:
- Bismuth-containing quadruple therapies are recommended for H. pylori in areas with high clarithromycin resistance.
- Single-capsule formulations of bismuth, metronidazole, and tetracycline show promise for H. pylori treatment.
- Antimicrobial susceptibility testing is advised after H. pylori treatment failures.
- The clinical impact of dysbiosis on IBS-C and microscopic colitis remains under investigation, requiring further research into microbiota manipulation.
Conclusions:
- Updated H. pylori treatment protocols emphasize bismuth therapies and susceptibility testing to combat antibiotic resistance.
- Further research into the gut microbiota's role in IBS-C and microscopic colitis is essential for developing effective therapeutic strategies.
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