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Updated: Feb 15, 2026

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
Published on: September 3, 2009
One-Parameter Scaling Theory for DNA Extension in a Nanochannel
E Werner1, G K Cheong2, D Gupta2
1Department of Physics, University of Gothenburg, SE-41296 Gothenburg, Sweden.
Abstract:
Experiments measuring DNA extension in nanochannels are at odds with even the most basic predictions of current scaling arguments for the conformations of confined semiflexible polymers such as DNA. We show that a theory based on a weakly self-avoiding, one-dimensional "telegraph" process collapses experimental data and simulation results onto a single master curve throughout the experimentally relevant region of parameter space and explains the mechanisms at play.
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