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The hitchhiker's guide to the chemical-biological galaxy
Giulia Opassi1, Alessandro Gesù2, Alberto Massarotti3
1Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale 'A. Avogadro', L.go Donegani 2, 28100 Novara, Italy; Current affiliation: Dept. of Chemistry - BMC, University of Uppsala, Husargatan 3, SE-751 23 Uppsala, Sweden.
Abstract:
We are used to considering chemical and biological spaces as two different entities; although they represent a more-interconnected world, in fact they represent a Yin-Yang concept in drug discovery. Chemical-biological space is as vast as the universe and, as Douglas Adams famously said, 'Space is big. You just won't believe how vastly, hugely, mind-bogglingly big it is'. However, many researchers are convinced that it is not so infinite, and are designing computational and experimental tools to help identify and explore all possible chemical-biological space. Here, we provide an analysis of their approaches and discuss possible future research studies.