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Alteration in microRNA-17-92 dynamics accounts for differential nature of cellular proliferation

Dola Sengupta1, Vinodhini Govindaraj1, Sandip Kar1

  • 1Department of Chemistry, IIT Bombay, Mumbai, India.

FEBS Letters
|January 14, 2018
PubMed

Insights

MicroRNAs from the mir-17-92 cluster regulate cell cycle progression. Their varied expression in cancers suggests targeting this network could control cell proliferation for cancer therapy.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Systems Biology

Background:

  • MicroRNAs (miRNAs) from the mir-17-92 cluster are key regulators of the mammalian cell cycle.
  • These miRNAs inhibit E2F transcription factors, which control cell cycle commitment and proliferation.
  • Aberrant mir-17-92 expression is observed in various cancers, with overexpression in solid tumors and downregulation in hematopoietic malignancies.
Keywords:
cancercellular proliferationmir-17-92

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