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Related Experiment Video

Updated: Feb 15, 2026

Neuroimaging Field Methods Using Functional Near Infrared Spectroscopy NIRS Neuroimaging to Study Global Child Development: Rural Sub-Saharan Africa
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Functional neuroimaging in Rasmussen syndrome.

Ichiro Kuki1, Kazumi Matsuda2, Yuko Kubota3

  • 1Department of Pediatrics, Osaka City University Graduate School of Medicine; National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders.

Epilepsy Research
|January 15, 2018
PubMed
Summary

Functional neuroimaging, including SPECT and PET scans, reveals abnormalities in Rasmussen syndrome (RS) even before MRI changes appear. These advanced techniques can detect seizure onset areas, aiding in diagnosis and understanding disease mechanisms.

Keywords:
Benzodiazepine receptorEncephalitisEpilepsyFocal cortical dysplasiaPositron emission tomography

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Area of Science:

  • Neurology
  • Neuroimaging
  • Epileptology

Background:

  • Rasmussen syndrome (RS) diagnosis relies on clinical, EEG, and MRI findings.
  • Limited research exists on functional neuroimaging in RS patients.
  • Investigating advanced imaging techniques can enhance diagnostic accuracy and understanding of RS.

Purpose of the Study:

  • To investigate cerebral blood flow (CBF)-SPECT, central benzodiazepine receptor (BZR)-SPECT, and FDG-PET in RS patients.
  • To correlate functional neuroimaging findings with MRI and pathological results.
  • To assess the utility of functional neuroimaging in early RS detection and characterization.

Main Methods:

  • Studied 23 RS patients (12 with histological diagnosis) using CBF-SPECT, BZR-SPECT, and FDG-PET.
  • Visually evaluated all imaging data.
  • Correlated imaging findings with MRI and histological examination results.

Main Results:

  • Interictal CBF-SPECT showed hypoperfusion in 16/22 patients; ictal CBF-SPECT revealed hyperperfusion in 10/12, correlating with EEG-identified ictal onset.
  • BZR-SPECT indicated reduced uptake in all 9 patients studied, including those with normal MRI.
  • FDG-PET demonstrated reduced metabolism in affected areas in all 5 patients; histology confirmed chronic encephalitis and focal cortical dysplasia in some.

Conclusions:

  • Functional neuroimaging reveals abnormalities in RS, sometimes preceding MRI changes.
  • BZR-SPECT and FDG-PET effectively detect ictal onset areas, even without MRI abnormalities.
  • RS-associated refractory seizures may involve impaired inhibitory neurons, as suggested by BZR-SPECT findings.