Related Experiment Video

Updated: Feb 15, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

817

Correlation between Serum Calcineurin Activity and Left Ventricular Hypertrophy in Hypertensive Patients and Its

Jia-Li Cao1, Yu-Qing Yang, Dookhun Muhammad Nabeel

  • 1Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Cardiology
|January 15, 2018
PubMed

Insights

Serum calcineurin (CaN) activity, not its level, correlates with hypertensive left ventricular hypertrophy (HLVH). CaN activity may serve as a key biomarker for diagnosing and predicting HLVH in hypertension patients.

Area of Science:

  • Cardiology
  • Biochemistry
  • Pathophysiology

Background:

  • Hypertension is a major risk factor for cardiovascular diseases.
  • Left ventricular hypertrophy (LVH) is a common complication of hypertension.
  • The role of calcineurin (CaN) in the development of hypertensive LVH requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between calcineurin (CaN) and hypertensive left ventricular hypertrophy (HLVH).
  • To evaluate the clinical significance of CaN in HLVH.
  • To determine if CaN levels or activity are associated with HLVH.

Main Methods:

  • Serum CaN levels and activity were measured in 118 hypertensive patients and 42 controls.
  • Hypertensive patients were classified into normal remodeling (HNM) and LVH (HLVH) subgroups.
  • Enzyme-linked immunosorbent assay and malachite green colorimetric assay were employed.

Main Results:

  • A positive correlation was found between serum CaN activity and HLVH, but not serum CaN level.
  • The HLVH subgroup showed significantly elevated levels of brain natriuretic peptide, cystatin C, urinary albumin/creatinine ratio, and left atrium diameter compared to HNM and controls.
  • These findings suggest CaN activity is linked to cardiac remodeling in hypertension.

Conclusions:

  • Serum CaN activity is positively correlated with LVH in hypertensive patients.
  • Activated CaN may play a significant role in the pathophysiology of HLVH.
  • Serum CaN activity shows potential as a clinical biomarker for diagnosing and predicting LVH in hypertension.
Abstract

Keywords:
CalcineurinCardiac hypertrophyHypertensionLeft ventricular hypertrophySignaling transduction

More Related Videos

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

25.6K
Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension04:49

Author Spotlight: Investigating the Underlying Mechanisms of Right Ventricular Failure in Pulmonary Hypertension

Published on: June 14, 2024

1.2K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
614
Correlations02:20

Correlations

Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.6K
Correlation and Causation01:27

Correlation and Causation

Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
43.0K
Statistical Significance01:50

Statistical Significance

Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
22.3K
Significance of Center of Mass01:12

Significance of Center of Mass

The center of mass of an object is defined as the mass-weighted average position of all the particles that comprise the object. The significance of the center of mass of an object can be seen by looking at its dynamics. The time derivative of the center of mass gives its velocity, assuming that the object's mass remains constant over time. Furthermore, the total linear momentum of an object can be seen as the linear momentum of a single particle of the object's total mass moving with...
7.8K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.5K