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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

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Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
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Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Modified-Release Drug Delivery Systems: Bioavailability01:30

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Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
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Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Updated: Feb 15, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release.

Qi Tang1, Bing Yu1,2, Lilong Gao1

  • 1Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

Current Medicinal Chemistry
|January 16, 2018
PubMed
Summary

Stimuli-responsive nanoparticles offer a promising strategy to improve cancer chemotherapy by enhancing drug efficacy and minimizing toxic side effects. This review highlights advancements in nanoparticle-based controlled drug delivery systems for safer and more effective cancer treatment.

Keywords:
Nanoparticleanti-cancerbioavailabilitychemotherapydrug releaseenhanced permeation and retention (EPR)stimuli responsive.

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Area of Science:

  • Nanotechnology
  • Material Science
  • Cancer Biology
  • Pharmaceutical Sciences

Background:

  • Conventional chemotherapy drugs exhibit significant toxic side effects and variable patient responses.
  • Nanoparticle-based drug delivery systems have been developed to overcome limitations of traditional chemotherapy.
  • Current nanomedicines show clinical promise but often fail to significantly enhance therapeutic efficacy.

Purpose of the Study:

  • To review recent advancements in stimuli-responsive nanoparticles for controlled anti-cancer drug release.
  • To explore how different stimuli (pH, temperature, light, redox) can be utilized for targeted drug delivery.
  • To assess the potential of these systems in improving cancer therapy efficacy and reducing side effects.

Main Methods:

  • Systematic review of literature on stimuli-responsive nanoparticles in cancer chemotherapy.
  • Analysis of nanoparticle designs responding to internal and external stimuli.
  • Evaluation of controlled drug release mechanisms and their impact on therapeutic outcomes.

Main Results:

  • Stimuli-responsive nanoparticles demonstrate potential for enhanced therapeutic efficacy.
  • These systems can achieve targeted drug release, reducing systemic toxicity and side effects.
  • Various stimuli-responsive mechanisms, including pH, temperature, light, and redox, are effective for controlled release.

Conclusions:

  • Stimuli-responsive nanoparticles represent a significant advancement in cancer drug delivery.
  • Further development holds promise for highly efficient and safe cancer therapies.
  • Responsive nanoparticles are expected to play a crucial role in future personalized cancer treatment strategies.