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Updated: Feb 15, 2026
Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
Published on: April 9, 2012
Plasma levels of Rifampicin and Pyrazinamide with pre and post meal administration in tuberculosis patients
Parveen Kumar Sharma1, Rekha Bansal2, Ashok Kumar Bhardwaj3
1Professor, Department of Pharmacology, SLBS Government Medical College, Mandi at Nerchowk, HP 175008, India.
Context:
Various factors affect plasma concentrations of antitubercular drugs in different populations so dosing schedule should be adjusted after therapeutic drug monitoring.
Aims:
To study variability in plasma concentrations of Rifampicin and Pyrazinamide with pre and post-meal administration of drugs in tuberculosis patients.
Methods And Material:
52 patients of pulmonary tuberculosis, divided in to two groups, pre and post-meal through systemic randomization. After taking pre-dose sample, drugs were administered according to the group. Samples were withdrawn at 2, 4, 6, and 10h after drug administration. Analysis of samples was done using HPLC.
Results:
Mean±1SD of Cmax of Rifampicin was 7.75±2.82μg/ml, mean±1SD of AUC0-10 was 42.17±17.25μgh/ml, adjusted Tmax was 4.25h. In pre-meal samples, the corresponding values were 7.75±2.88μg/ml, 42.83±18.47μgh/ml, 3.76h and in post-meal samples 8.03±2.30μg/ml, 41.56±16.46μgh/ml and 4.75h. Mean±1SD of Cmax levels of Pyrazinamide was 54.49±21.86μg/ml, mean±1SD of AUC0-10 was 337.94±124.28μgh/ml and adjusted Tmax was 3.49h. In pre-meal samples the corresponding values were 52.00±19.13μg/ml, 329.96±112.11μgh/ml, 3.23h, and in post-meal samples 57.43±23.61μg/ml, 345.58±136.99μgh/ml, 3.54h.
Conclusion:
There is huge variability in the plasma levels of Rifampicin and Pyrazinamide in population of this sub-himalayan region.
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