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Calcified Amorphous Tumor-Induced Acute Cerebral Infarction

Yoshihiro Aizawa1, Toshiko Nakai1, Yuki Saito1

  • 1Division of Cardiology, Department of Medicine, Nihon University School of Medicine.

International Heart Journal
|January 16, 2018
PubMed

Insights

A cardiac calcified amorphous tumor (CAT) caused a stroke in a 38-year-old woman. Surgical removal and valve replacement revealed calcium build-up and tissue rupture may cause CAT formation.

Area of Science:

  • Cardiology
  • Neurology
  • Pathology

Background:

  • Cardiac calcified amorphous tumors (CATs) are rare and can lead to embolic events.
  • Mitral annular calcification (MAC) is a common finding, particularly in older adults, and is associated with cardiovascular disease.

Observation:

  • A 38-year-old woman presented with acute cerebral infarction.
  • The infarction was linked to a cardiac calcified amorphous tumor (CAT) and associated mitral annular calcification (MAC).

Findings:

  • The cardiac mass was surgically removed, and mitral valve replacement was performed.
  • Pathological examination showed degenerating material in both the CAT and MAC.
  • Findings suggest that calcium accumulation along the mitral annulus and subsequent fibrotic tissue rupture may initiate and drive CAT development.

Implications:

  • This case highlights a potential mechanism for CAT formation related to MAC.
  • Understanding this pathway could inform future diagnostic and therapeutic strategies for embolic stroke prevention.
  • Further research is warranted to elucidate the precise relationship between MAC and CAT formation.

Keywords:
Cardiac tumorCardiogenic cerebral embolismEchocardiography

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