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The Management of Post Analytical Correction Factors
Roger Barton1, Mark Mackay2, Graham Rd Jones3
1Southern Community Laboratories, Dunedin, New Zealand.
The Clinical Biochemist. Reviews
|January 16, 2018
Summary
Clinical laboratories use Post Analytical Correction Factors (PACF) to standardize assay results across different methods. These factors ensure accurate patient data comparison by using commutable materials and formal management processes.
Area of Science:
- Clinical Chemistry
- Laboratory Medicine
- Biotechnology
Background:
- Clinical laboratories often need to compare assay results obtained from various analytical methods.
- Standardization is crucial for aligning patient results with reference intervals and clinical decision points.
Purpose of the Study:
- To introduce and define Post Analytical Correction Factors (PACF) used in clinical laboratories.
- To outline preliminary guidelines for the establishment, application, and management of PACF.
Main Methods:
- Exploration of the systematic application of correction factors to assay results post-analysis.
- Emphasis on the use of commutable materials, such as patient samples, for establishing PACF.
- Discussion of a formal process for managing PACF within laboratory workflows.
Main Results:
- Post Analytical Correction Factors (PACF) can be applied to quality control (QC), external quality assurance (EQA), and patient results.
- The primary utility of PACF lies in enabling the comparison of patient results across different methods.
- Preliminary guidelines for PACF were developed based on a recent workshop.
Conclusions:
- Implementing PACF requires careful consideration of material commutability and a structured management approach.
- Standardized reporting through PACF enhances data comparability and clinical utility.
- Further development and adoption of PACF guidelines are recommended for clinical laboratories.
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