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Updated: Feb 15, 2026
06:32
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
Published on: October 24, 2016
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Minimally Invasive Electrochemotherapy Procedure for Treating Nasal Duct Tumors in Dogs using a Single Needle
Felipe Maglietti1,2,3, Matías Tellado4, Nahuel Olaiz1,2,3
1Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Física, Buenos Aires, Argentina.
Radiology and Oncology
|January 16, 2018
Summary
Electrochemotherapy (ECT) using a novel single needle electrode (SiNE) offers a minimally invasive treatment for nasal tumors in dogs, significantly improving survival rates compared to traditional methods.
Area of Science:
- Veterinary Oncology
- Minimally Invasive Procedures
- Cancer Therapeutics
Background:
- Nasal cavity tumors often present late, necessitating aggressive treatments with significant side effects.
- Electrochemotherapy (ECT) is an established treatment for superficial tumors.
- Treating deep-seated nasal tumors with ECT is limited by the ability to deliver an effective electric field.
Purpose of the Study:
- To evaluate the efficacy and safety of ECT using a single needle electrode (SiNE) for treating nasal tumors in canine patients.
- To compare the outcomes of SiNE-ECT with surgery plus adjuvant chemotherapy.
Main Methods:
- A minimally invasive single needle electrode (SiNE) was developed to deliver electric fields for ECT.
- Twenty-one dogs with spontaneous nasal tumors were enrolled: 11 received SiNE-ECT, and 10 served as a control group (surgery + chemotherapy).
Main Results:
- The SiNE-ECT group achieved a 91% objective response rate (27% complete, 64% partial response).
- Mean overall survival in the SiNE-ECT group was 16.86 months, significantly longer than the control group (p = 0.0008).
- One-year survival was 60% for SiNE-ECT versus 10% for controls; 30% remained alive at 32 months versus 0% for controls.
Conclusions:
- Electrochemotherapy with the single needle electrode (SiNE) is a safe and effective treatment for nasal tumors in dogs.
- SiNE-ECT demonstrates encouraging results and improved survival rates in canine nasal tumor patients.
- This minimally invasive approach overcomes limitations of traditional ECT for deep-seated tumors.
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