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Related Experiment Video

Updated: May 15, 2026

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Published on: November 28, 2017

Electrode Tip Wear Increases Needle Deflection and Procedural Complexity in Electrochemotherapy.

Ana Campastri^1,2, Antonella Cilio^1,2, Marina Ribeiro¹

¹Instituto Universitario de Ciencias de la Salud Fundación HA Barceló-CONICET, Buenos Aires, Argentina.

|May 14, 2026

Summary

Triangular needle tips offer superior performance in electrochemotherapy (ECT) by maintaining sharpness longer and requiring less force for insertion. This improves electric field distribution and reduces tissue trauma during cancer treatment.

Keywords:

dermatology electroporation needles oncology veterinary

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Electrochemotherapy of Tumours

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Last Updated: May 15, 2026

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Fabrication of Fine Electrodes on the Tip of Hypodermic Needle Using Photoresist Spray Coating and Flexible Photomask for Biomedical Applications

Published on: November 28, 2017

Electrochemotherapy of Tumours

Electrochemotherapy of Tumours

Published on: December 15, 2008

Area of Science:

Medical Devices
Oncology
Biomedical Engineering

Background:

Electrochemotherapy (ECT) is a standard treatment for skin cancers.
Current needle electrodes degrade quickly, causing tissue trauma and uneven electric field distribution.
Veterinary electrodes often have sharper tips than human medical electrodes.

Purpose of the Study:

To evaluate the performance of different needle tip geometries for electrochemotherapy.
To assess insertion force, needle sharpness degradation, and electric field distribution.
To investigate the efficacy of a guiding mask in minimizing needle deflection.

Main Methods:

Compared conical, beveled, and triangular needle tips (7 mm diameter).
Utilized COMSOL Multiphysics® simulations for electric field analysis.
Evaluated insertion force and sharpness loss using an ex vivo model.
Tested a guiding mask to reduce needle deflection.

Main Results:

Triangular tips required the least insertion force and maintained sharpness for up to 200 insertions.
Conical tips degraded fastest (approx. 50 insertions), followed by beveled (approx. 150 insertions).
A guiding mask significantly reduced needle deflection, improving alignment and electric field uniformity.

Conclusions:

Triangular needle tips offer superior insertion efficiency and durability for electrochemotherapy.
Optimized needle design and guiding masks can enhance ECT efficacy and patient outcomes.
Further research into electrode design can minimize treatment-related complications.