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A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
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Brentuximab vedotin: clinical updates and practical guidance
Jun Ho Yi1, Seok Jin Kim2, Won Seog Kim2
1Division of Hematology-Oncology, Department of Medicine, Chung-Ang University Hospital, Seoul, Korea.
Blood Research
|January 16, 2018
Summary
Brentuximab vedotin (BV) is an effective antibody-drug conjugate for CD30-positive lymphomas. This review details recent clinical trial updates and practical guidance for using BV in practice.
Area of Science:
- Oncology
- Pharmacology
- Immunotherapy
Background:
- Brentuximab vedotin (BV) is an antibody-drug conjugate targeting the CD30 antigen.
- BV demonstrated significant efficacy in CD30-positive lymphomas, leading to its accelerated approval in 2011.
- Subsequent large-scale trials have expanded the understanding and application of BV.
Purpose of the Study:
- To provide a comprehensive review of the latest clinical trial findings for Brentuximab vedotin.
- To offer updated, in-practice guidance for the clinical use of BV.
- To summarize the evolving role of BV in treating CD30-positive malignancies.
Main Methods:
- Systematic literature review of clinical trials involving Brentuximab vedotin.
- Analysis of data from large-scale studies and post-approval investigations.
- Synthesis of clinical evidence to inform practical usage guidelines.
Main Results:
- BV has shown remarkable efficacy in Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma.
- Numerous trials have supported the extension of BV's indications beyond its initial approval.
- Updated data confirm BV's established role and explore new therapeutic contexts.
Conclusions:
- Brentuximab vedotin remains a cornerstone therapy for CD30-positive lymphomas.
- Continuous research and clinical experience are refining the optimal use of BV.
- This review consolidates current knowledge for effective clinical application of BV.
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