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Related Concept Videos

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Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
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The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
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Updated: Feb 15, 2026

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
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Surrogate scale for evaluating respiratory function based on complete blood count parameters.

Yang Guang1, Zhou Jie1, Dong Feng1

  • 1College of Medical Laboratory, Dalian Medical University, Dalian, China.

Journal of Clinical Laboratory Analysis
|January 16, 2018
PubMed
Summary
This summary is machine-generated.

A new Red Cell Index (RCI) derived from complete blood count parameters offers a simple method for evaluating respiratory function. This index showed significant relationships with respiratory measures in COPD and aged subjects.

Keywords:
COPDblood countcomputer-assisted diagnosisrespiratory function

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Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Biostatistics

Background:

  • Evaluating respiratory function typically requires specialized equipment.
  • A simple, accessible method for assessing lung health is needed, particularly for conditions like COPD.

Purpose of the Study:

  • To investigate the utility of complete blood count (CBC) parameters for a simple respiratory function assessment.
  • To develop and validate a novel index, the Red Cell Index (RCI), for this purpose.

Main Methods:

  • CBC parameters (RBC, Hb, Lym, Plt) and partial pressure of oxygen (PO2) were measured in COPD patients, aged individuals, and young controls.
  • The Red Cell Index (RCI) was calculated as (RBC × Hb) / (Lym × Plt).
  • Statistical analyses were performed to correlate RCI with established respiratory function measures (PCO2, FEV1/FVC).

Main Results:

  • The RCI demonstrated significant correlations with PCO2 and FEV1/FVC values (P < .05).
  • RCI values were significantly elevated in COPD and aged groups compared to controls (P < .05).
  • A cutoff value of 2.3 for RCI indicated normal respiratory function, with higher positive rates for abnormal RCI in patient groups.

Conclusions:

  • The Red Cell Index (RCI) serves as a simple and effective tool for evaluating respiratory function.
  • CBC-derived RCI offers a potential non-invasive biomarker for respiratory health assessment.