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Related Experiment Video

Updated: Jun 23, 2026

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

Reference Interval Establishment for Four Coagulation Parameters Using Indirect Methods in a High-Altitude Chinese

Banjiu Zhaxi1, Danni Mu1, Shengfang Ye2

  • 1Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.

Journal of Clinical Laboratory Analysis
|June 22, 2026
PubMed
Summary

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This summary is machine-generated.

Reference intervals for coagulation parameters in Tibet differ significantly from plains populations. Establishing high-altitude specific reference intervals (RIs) is crucial for accurate diagnosis of coagulation disorders.

Area of Science:

  • Clinical Biochemistry
  • Hematology
  • High-Altitude Physiology

Background:

  • Coagulation parameters are vital for diagnosing hemostatic disorders.
  • Existing reference intervals (RIs) may not be suitable for high-altitude populations due to physiological differences.
  • Tibet, a high-altitude region, requires specific RIs for accurate clinical assessment.

Purpose of the Study:

  • To establish reference intervals (RIs) for four key coagulation parameters in the adult Tibetan population.
  • To compare these RIs with those used in lower-altitude regions and manufacturer-provided values.
  • To determine the necessity of high-altitude specific RIs for coagulation testing.

Main Methods:

  • Utilized indirect methods (Hoffmann and refineR) to calculate RIs.
Keywords:
Tibetcoagulationhypoxiaindirect methodreference interval

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Last Updated: Jun 23, 2026

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
05:35

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

  • Analyzed coagulation data including Activated Partial Thromboplastin Time (APTT), Prothrombin Time (PT), Thrombin Time (TT), and Fibrinogen (FIB).
  • Applied Box-Cox transformation for normalization and Tukey method for outlier removal.

    • Main Results:

    • Established RIs for APTT, PT, TT, and FIB in the Tibetan population.
    • Found significant differences: APTT and FIB RIs were higher, while TT RIs were lower compared to plains populations.
    • Gender-partitioned RIs were calculated for all parameters; age-partitioned RIs for PT and FIB.

    Conclusions:

    • Coagulation parameter RIs in Tibet significantly diverge from those in plains areas.
    • High-altitude specific RIs are essential for accurate evaluation of coagulation disorders in the Tibetan population.
    • This study provides crucial data for optimizing coagulation testing in high-altitude environments.