Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hematopoiesis

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reference Interval Establishment for Four Coagulation Parameters Using Indirect Methods in a High-Altitude Chinese Population: A Retrospective Real-World Analysis.

Journal of clinical laboratory analysis·2026

Same author

Interfacial Regulation-Driven Dual-Enrichment SERS Coupled With Deep Learning Enable Ultrasensitive and In Situ Identification of Microplastics in Natural Waters.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

BolMYB122-BolTGG1 module enhances salt stress tolerance via accelerating the hydrolysis of glucosinolates to produce sulforaphane in broccoli.

Plant physiology and biochemistry : PPB·2026

Same author

Predictive efficacy of PASP combined with NT-proBNP for outcomes in pregnant women with severe cardiovascular disease: a single-centre retrospective observational study.

BMC pregnancy and childbirth·2026

Same author

Long-term efficacy of the treat-to-close strategy for patients with atrial septal defect-pulmonary artery hypertension and characteristics of indicated populations.

Clinics (Sao Paulo, Brazil)·2026

Same author

Designing and Evaluating an Autoverification RCV-Based System for Thyroid Function Profiles.

Diagnostics (Basel, Switzerland)·2026

Same journal

Correction: Luca et al. Global and Regional Diagnostic Results of Progress Toward Cervical Cancer Elimination, According to the WHO Strategy: A Systematic Literature Review with Narrative Synthesis. <i>Diagnostics</i> 2026, <i>16</i>, 1224.

Diagnostics (Basel, Switzerland)·2026

Same journal

Association Between Systemic Inflammatory Response Biomarkers and Disease Activity in Systemic Lupus Erythematosus: A Multi-Center Retrospective Study.

Diagnostics (Basel, Switzerland)·2026

Same journal

Vertebrogenic Low Back Pain and Basivertebral Nerve Ablation: A Review of Mechanisms, Imaging-Driven Selection, and Clinical Outcomes.

Diagnostics (Basel, Switzerland)·2026

Same journal

Multivalvular Carcinoid Heart Disease: The Role of Echocardiography in Diagnosis and Selection for Heterotopic Bicaval Valve Implantation.

Diagnostics (Basel, Switzerland)·2026

Same journal

Data-Efficient and Explainable Multimodal Survival Prediction in NSCLC Using Deep Image Embeddings, Clinical Variables, and Gradient-Boosted Trees.

Diagnostics (Basel, Switzerland)·2026

Same journal

Anomalous Left Coronary Artery from the Pulmonary Artery: Cinematic Volume Rendering Technique for Enhanced Anatomic Visualization.

Diagnostics (Basel, Switzerland)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

Establishment and Temporal Validation of Next-Generation Reference Intervals for Routine Hematological Parameters

Chaochao Ma^1,2, Lihua Guan¹, Qian Chen¹

¹Department of Laboratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100730, China.

Diagnostics (Basel, Switzerland)

|March 28, 2026

Summary

This summary is machine-generated.

Next-generation reference intervals (NGRIs) provide dynamic, age- and sex-specific limits for hematological parameters. These stable NGRIs, derived from large health data, improve laboratory medicine accuracy across the lifespan.

Keywords:

GAMLSS age-continuous modeling big data hematological parameters next-generation reference intervals temporal validation

More Related Videos

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Related Experiment Videos

Last Updated: Mar 29, 2026

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

Published on: November 3, 2018

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

Area of Science:

Clinical Biochemistry
Hematology
Biostatistics

Background:

Conventional reference intervals (RIs) are static and fail to capture continuous biological variation.
Next-generation reference intervals (NGRIs) offer dynamic modeling across age and sex.
Existing RIs may not adequately represent diverse populations.

Purpose of the Study:

To establish age- and sex-specific NGRIs for routine hematological parameters.
To evaluate the temporal stability of these NGRIs.
To utilize large-scale health examination data for NGRIs.

Main Methods:

Defined a healthy reference population (18-80 years) from health examination data.
Employed generalized additive models for location, scale, and shape (GAMLSS) with Box-Cox Cole and Green distribution.
Generated age-dependent percentile curves and validated temporally across five annual cohorts (2019-2023).

Main Results:

Observed significant age- and sex-dependent patterns in RBC, HGB, and HCT.
Continuous percentile curves revealed gradual age-related trends, with notable female changes post-midlife.
Temporal validation showed consistent performance with <10% individuals outside intervals.

Conclusions:

Established stable, age-continuous NGRIs for routine hematological parameters using real-world data.
The GAMLSS approach offers a reproducible strategy for modernizing RI construction.
This method supports broader implementation in population-based laboratory medicine.