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Three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds
Bo-Sheng Zhang1, Lu-Yao Gao, Zhe Zhang
1State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China. liangym@lzu.edu.cn.
Abstract:
This report describes a new method for three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds via air-stable SCF3 and SeCF3 reagents as free-radical initiators of ethyl iododifluoroacetate. β-Proton elimination can be overcome effectively in this reaction system, and a broad substrate scope, including alkenes and alkynes, makes this approach practical and attractive.
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