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Updated: Feb 15, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
Published on: December 1, 2023
Preoperative optimization of ocular surface disease before cataract surgery
Jasmine Chuang1, Kendrick Co Shih1, Tommy C Chan1
1From the Li Ka Shing Faculty of Medicine (Chuang) and the Department of Ophthalmology (Shih), University of Hong Kong, the Department of Ophthalmology and Visual Sciences (Chan, Jhanji), Faculty of Medicine, the Chinese University of Hong Kong, Department of Ophthalmology (Wan), Tuen Mun Eye Centre and Tuen Mun Hospital, Hong Kong, China; the Department of Ophthalmology (Jhanjij), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania USA; the Ocular Surface Research Group (Tong), Singapore Eye Research Institute, the Corneal and External Eye Disease Service (Tong), Singapore National Eye Centre, the Eye-Academic Clinical Program (Tong), Duke-NUS Medical School, and the Department of Ophthalmology (Tong), Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Abstract:
An impaired ocular surface adversely affects preoperative planning for cataract surgery, including intraocular lens (IOL) calculations, toric IOL axis and magnitude estimates, keratometry, and topography measurements. It also increases surgical difficulty. We performed a review to evaluate the connection between cataract surgery and dry eye and to determine the best management for these patients. Of the 16 papers included in this review, 6 were randomized controlled trials. Cataract surgery was shown to worsen ocular parameters and aggravate dry-eye disease. Physicians should recognize and aggressively treat cataract patients with poor prognostic factors and/or with existing dry-eye disease. Increased incision extent, operation time, irrigation, and microscopic-light exposure time decreased the tear breakup time and mean goblet cell density. Postoperatively, the use of eyedrops was associated with worsening of goblet cell density; hence, these medications should be tapered off when no longer needed.
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