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Neuropathic Corneal Pain and Blepharospasm: A Case Series
Zhang Zhe Thia1, Aya Takahashi1, Mingyi Yu1
1Regenerative Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Diagnostics (Basel, Switzerland)
|July 15, 2026
Summary
Blepharospasm may predispose individuals to neuropathic corneal pain by irritating trigeminal nerves. Concurrent treatment of both conditions with a multimodal approach can significantly improve symptoms and quality of life.
Area of Science:
- Ophthalmology
- Neurology
- Pain Management
Background:
- Neuropathic corneal pain involves ocular pain disproportionate to clinical signs, often due to corneal somatosensory pathway sensitization.
- Chronic blepharospasm (involuntary eyelid muscle contraction) may irritate trigeminal nerves, potentially leading to corneal neurogenic inflammation and neuropathic corneal pain.
- Early identification of blepharospasm as a predisposing factor is crucial to prevent neuropathic sequelae.
