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Updated: Feb 15, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Biomimetic Enantioselective Total Synthesis of (-)-Petromindole
Dattatraya H Dethe1, Susanta Kumar Sau1
1Department of Chemistry, Indian Institute of Technology Kanpur , Kanpur-208016, India.
Abstract:
The first enantioselective total synthesis of (-)-petromindole, an architecturally distinct congener of indole diterpene family, has been achieved. Key features of this synthetic route include the scalable and concise synthesis of tricyclic allylic alcohol from enantiopure Wieland-Mischer ketone derivative, and TMSOTf-mediated, highly efficient biomimetic C-4 cyclization of indole derivative for the rapid construction of a hexacyclic skeleton of petromindole.
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