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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Related Experiment Video

Updated: Feb 15, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
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Back to the future: Epigenetic clock plasticity towards healthy aging.

Ken Declerck1, Wim Vanden Berghe1

  • 1Laboratory of Protein Chemistry, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp (UA), Belgium.

Mechanisms of Ageing and Development
|January 17, 2018
PubMed
Summary

Biological age, measured by epigenetic DNA methylation clocks, predicts health and disease risk. Understanding these clocks can guide lifestyle choices for healthier aging and extended lifespan.

Keywords:
AgeAgingClockDietDiseaseEpigeneticHealthyInflammationLifestyleNutrition

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Area of Science:

  • Gerontology
  • Epigenetics
  • Biomarkers

Background:

  • Aging is a primary risk factor for major diseases like cancer and cardiometabolic disorders.
  • Individual aging rates vary due to complex genetic, lifestyle, and environmental interactions.
  • A biochemical biomarker for biological age is needed to predict health status and disease risk.

Purpose of the Study:

  • To highlight the utility of epigenetic DNA methylation clocks as biomarkers for biological age.
  • To discuss the application of epigenetic clocks in assessing aging disease susceptibility and mortality risk.
  • To explore the potential of epigenetic clocks as tools for lifestyle management and extending health span.

Main Methods:

  • Utilizing DNA methylation patterns to construct epigenetic clock predictors.
  • Analyzing epigenetic clock signatures as biomarkers.
  • Investigating the mechanisms underlying the epigenetic aging clock.

Main Results:

  • Epigenetic clocks accurately predict biological age, reflecting functional health relative to chronological age.
  • Epigenetic clock signatures are increasingly used to estimate disease susceptibility and mortality.
  • These clocks offer insights into aging processes and potential interventions.

Conclusions:

  • Epigenetic clocks serve as valuable biomarkers for biological age and health status.
  • They can guide lifestyle interventions to promote healthy aging and extend lifespan.
  • Further research into epigenetic clock mechanisms can reveal ways to manipulate aging for improved health span.