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Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons
Published on: October 18, 2017
Modelling non-Markovian fluctuations in intracellular biomolecular transport
Wilson I Barredo1, Christopher C Bernido2, M Victoria Carpio-Bernido2
1Physics Department, MSU-Iligan Institute of Technology, Tibanga, Iligan City, 9200, Philippines; Physics Department, Mindanao State University, Marawi City, 9700, Philippines.
Abstract:
To model non-Markovian fluctuations arising in biomolecular transport, we introduce a stochastic process with memory where Brownian motion is modulated sinusoidally. The probability density function and moments of this non-Markovian process are evaluated analytically as Hida stochastic functional integrals. Comparison of graphs of computed variance vis-á-vis empirical data for protein diffusion coefficients closely match with both exhibiting emergent superdiffusive then subdiffusive behavior for longer proteins.
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