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Making Use of Cancer Genomic Databases
Chad J Creighton1,2,3,4
1Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Current Protocols in Molecular Biology
|January 17, 2018
Summary
Vast cancer genomic data is available in public repositories, offering rich resources for researchers. While user-friendly tools exist, skilled bioinformaticians are still needed for complex analyses of this large-scale genomic data.
Area of Science:
- Genomics
- Bioinformatics
- Cancer Research
Background:
- Public repositories contain extensive genomic data from over 10,000 human tumors.
- Initiatives like The Cancer Genome Atlas provide multi-platform molecular profiling data (mutation, expression, methylation).
Purpose of the Study:
- To introduce researchers to available resources for working with cancer genomic databases.
- To highlight the complementary roles of user-friendly software and skilled bioinformatics analysts.
Main Methods:
- Overview of existing public cancer genomic databases and data types.
- Discussion of software tools for biologists and the need for bioinformatics expertise.
Main Results:
- Numerous resources exist for accessing and analyzing large-scale cancer genomic data.
- A gap remains in addressing complex research questions that require advanced bioinformatics skills.
Conclusions:
- Cancer genomic databases are valuable resources for the research community.
- Effective utilization requires both accessible tools and specialized bioinformatics support.
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