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[Angiology and haemostasis. Highlights on some new data in 2017].
Pierre Fontana1, Helia Robert-Ebadi1, Françoise Boehlen1
1Service d'angiologie et d'hémostase, HUG, 1211 Genève 14.
Revue Medicale Suisse
|January 17, 2018
Summary
Direct oral anticoagulants are effective for preventing venous thromboembolism in specific patients. New data also cover dabigatran reversal and the potential of emicizumab for haemophilia A management.
Area of Science:
- Pharmacology
- Hematology
Background:
- Venous thromboembolism (VTE) poses a significant health risk.
- Direct oral anticoagulants (DOACs) are increasingly used for VTE prevention.
- Management of bleeding complications and specific bleeding disorders requires ongoing research.
Purpose of the Study:
- To review the efficacy and safety of long-term prophylactic anticoagulation with DOACs.
- To present updated information on idarucizumab for dabigatran reversal.
- To discuss the potential of emicizumab in managing haemophilia A.
Main Methods:
- Review of recent clinical data and studies.
- Analysis of safety profiles for anticoagulants and reversal agents.
- Evaluation of emerging therapies for bleeding disorders.
Main Results:
- Prophylactic anticoagulation with DOACs demonstrates effectiveness and safety for long-term VTE prevention in select patient groups.
- Updated data on idarucizumab provide further support for its role in managing major bleeding associated with dabigatran.
- Emicizumab shows promise as a novel therapeutic agent for haemophilia A, potentially transforming patient management.
Conclusions:
- DOACs are a valuable tool for long-term VTE prophylaxis in indicated patients.
- Idarucizumab is a crucial agent for reversing dabigatran-related bleeding.
- Emicizumab represents a significant advancement in the treatment landscape for haemophilia A.
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