Related Experiment Video

Updated: Feb 15, 2026

An Aptamer-based Sensor for Unchelated GadoliniumIII
05:15

An Aptamer-based Sensor for Unchelated GadoliniumIII

Published on: January 9, 2017

7.8K

Frequency and Severity of Acute Allergic-Like Reactions to Intravenously Administered Gadolinium-Based Contrast Media

Monica M Forbes-Amrhein1, Jonathan R Dillman, Andrew T Trout

  • 1From the Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Investigative Radiology
|January 17, 2018
PubMed

Insights

Allergic-like reactions to gadolinium-based contrast media (GBCM) in children are rare and similar across different agents. A temporary increase in reactions was noted during a GBCM transition period, likely due to the Weber effect.

Area of Science:

  • Pediatric Radiology
  • Pharmacovigilance
  • Medical Imaging

Background:

  • Gadolinium-based contrast media (GBCM) are essential for pediatric imaging.
  • Transitioning between GBCM agents requires careful monitoring for adverse events.
  • Understanding reaction frequencies is crucial for patient safety.

Purpose of the Study:

  • To determine the frequency and severity of acute allergic-like reactions to GBCM in children.
  • To compare reaction rates before, during, and after a switch from gadopentetate dimeglumine to gadoterate meglumine.
  • To assess the safety profile of gadoterate meglumine in a pediatric population.

Main Methods:

  • Retrospective analysis of 32,365 GBCM administrations in pediatric patients (2009-2017).
  • Identification and classification of allergic-like reactions from institutional databases.
  • Comparison of reaction frequencies between different GBCM agents using chi-squared tests.

Main Results:

  • Overall allergic-like reaction frequency to GBCM was low (0.06%).
  • No significant difference in reaction rates was found among gadofosveset trisodium, gadoxetate disodium, gadoterate meglumine, and gadopentetate dimeglumine.
  • A transient increase in reaction frequency (0.20%) was observed during the transition period from gadopentetate dimeglumine to gadoterate meglumine.

Conclusions:

  • Allergic-like reactions to GBCM in children are rare and generally mild to moderate.
  • Gadoterate meglumine demonstrates a comparable safety profile to other GBCMs.
  • The observed increase in reactions during the transition period is likely attributable to the Weber effect, not an inherent property of the new GBCM.
Abstract

More Related Videos

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

28.5K
How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children07:27

How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children

Published on: August 19, 2020

12.6K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
32.5K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
18
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
16
Acids, Bases and Neutralization Reactions03:26

Acids, Bases and Neutralization Reactions

An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
64.0K
Acids, Bases and Neutralization Reactions01:27

Acids, Bases and Neutralization Reactions

Acids and bases play several important roles in biology. The pH of a biological system can significantly impact the function of biological molecules, including enzymes, proteins, and nucleic acids. For example, enzymes have optimal pH ranges for their activity, and changes in pH can denature or alter their structure, affecting their function. Acids and bases also play a crucial role in cellular signaling and communication. The pH of the extracellular fluid around cells can influence the...
10.8K