Palladium-Catalyzed Four-Component Cascade Reaction for the Synthesis of Highly Functionalized Acyclic O,O-Acetals
Wenfang Xiong1, Donghao Yan1, Chaorong Qi1
1Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
Abstract:
A palladium-catalyzed four-component cascade reaction of carbon dioxide, amines, allenyl ethers, and aryl iodides has been developed for the first time. The novel reaction allows simultaneous construction of three different new bonds (C-N, C-O, and C-C) in a single step, affording an efficient method for the synthesis of a variety of highly functionalized acyclic O,O-acetals. Excellent chemo- and regioselectivity, wide substrate scope, and good functional group tolerance are features of the method.
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