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Updated: Feb 15, 2026

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines
Janaína M Santos1, Nathalia M Cury2, José A Yunes2,3
1a Programa de Pós-Graduação em Biotecnologia Industrial, Universidade Tiradentes/Instituto de Tecnologia e Pesquisa , Aracaju , Brasil.
Abstract:
Anacardium occidentale leaves are used in folk medicine due its therapeutic properties attributed to phenolic compounds. Therefore, this study was undertaken on its hydroethanolic leaf extract (AoHE) to evaluate cytotoxicity and apoptosis induction on acute lymphoblastic leukaemia cells. Results indicated that AoHE interfered in the cell cycle progression, inducing apoptosis by activation of casp3 at lower concentrations, thence, a promising candidate for the development of new cancer drugs.
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