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Updated: Feb 15, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
New compounds with antimicrobial activities from Elaeodendron buchananii stem bark
Jenipher Akinyi Odak1, Lawrence Onyango Arot Manguro1, Keng-Chong Wong2
1a Chemistry Department , Maseno University , Maseno 40105 , Kenya.
Abstract:
The plant species Elaeodendron buchananii Loes is widely used in folklore medicine to manage microbial infections in Kenya. Previous studies on the plant fruits and root bark revealed the presence of steroids and terpenoids. The present phytochemical analysis of the plant stem bark has led to the isolation of four new triterpenes characterized as methyl 3β-acetoxy-11α, 19α, 28-trihydroxyurs-12-en-23-oic acid (1), 3β, 11α, 19α-trihydroxyurs-12-en-23, 28-dioic acid (2), 3β-acetoxy-19α, 23, 28-trihydroxyurs-12-ene (3) and 3-oxo-19α, 28-dihydroxyurs-12-en-24-oic acid (4), together with ten known ones (5-14), whose structures were elucidated using spectroscopic techniques. The isolate canophyllol (8) showed promising antibacterial activity against N. meningitides with MIC value of 31.25 μg/ml.
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