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Hematopoietic and mesenchymal stem cells: a promising new therapy for spondyloarthritis?

Valeria Rios Rodriguez1, Maria Llop2, Denis Poddubnyy1

  • 1Department of Gastroenterology, Infectiology & Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Germany.

Immunotherapy
|January 18, 2018
PubMed

Insights

Stem cell transplantation, including hematopoietic and mesenchymal stem cells, shows promise for treating spondyloarthritides. Further research is needed to address treatment gaps for patients unresponsive to current therapies.

Area of Science:

  • Immunology
  • Rheumatology
  • Regenerative Medicine

Background:

  • Spondyloarthritides treatments have advanced, yet many patients remain unresponsive to current therapies.
  • Stem cell transplantation has been explored for autoimmune diseases since the late 1990s.
  • Mesenchymal stem cells are increasingly studied for their low immunogenicity and immunomodulatory potential.

Purpose of the Study:

  • To review existing data on stem cell transplantation for spondyloarthritides.
  • To evaluate the efficacy of hematopoietic stem cell transplantation (HSCT) and mesenchymal stem cell (MSC) therapy.
  • To identify research gaps and propose future research directions in this field.

Main Methods:

  • Systematic review of published clinical trials and research studies.
  • Analysis of data concerning HSCT and MSC applications in spondyloarthritides.
  • Literature synthesis to summarize current evidence and identify unmet needs.

Main Results:

  • Hematopoietic stem cell transplantation has been investigated as a treatment option.
  • Mesenchymal stem cells demonstrate potential due to their immunomodulatory properties.
  • Significant data gaps exist, necessitating further investigation into optimal protocols and long-term outcomes.

Conclusions:

  • Stem cell therapies, particularly MSCs, offer a potential new avenue for spondyloarthritides management.
  • Addressing current treatment limitations requires further research into stem cell applications.
  • Future research should focus on defining the role of HSCT and MSCs in spondyloarthritides therapy.
Keywords:
ankylosing spondylitishematopoietic stem cellsmesenchymal cellspsoriatic arthritisspondyloarthritistreatment

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